Hawthorn will be without two of its star players when it takes on Port Adelaide this Saturday, with James Sicily and Jaeger O'Meara both ruled out.

In bad news confirmed yesterday, James Sicily has ruptured his ACL and will commence a 12-month rehabilitation following surgery.

Read: Sis dealt injury blow

Vice Captain Jaeger O'Meara is also set for surgery to have a plate put in his hand, following an incident early in Sunday's game.

"Unfortunately Jaeger's fractured his hand in the game in the first quarter," Physical Performance Manager Luke Boyd said.

"It was a pretty gallant effort from him to get through the game. He's going to have surgery this week which'll obviously rule him out (for this week's game).

"We'll reassess next week and see whether he's available to play."

Youngster Harry Jones has also been dealt his own injury setback, with the 21-year-old sustaining an MCL injury in Sunday's scrimmage game.

"It's a different injury to what he's had in the past," Boyd confirmed; Jones missed the latter part of last year with a PCL injury.

"It looks like a four to six week rehab to return to play for Harry."

Watch this week's injury report for all the latest injury news.

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Hawthorn's Injury list:

Isaac Smith - shoulder - test
Jaeger O'Meara - hand - 1-2 weeks
Ricky Henderson - knee - 2 weeks
Harrison Jones - MCL - 4-6 weeks
James Sicily - ACL - season
Will Golds - ACL - season